11 b l.y. <------------------- US --------------------> 11 b l.y. CMBR CMBR
Diametrically opposed regions on the sky require longer than the age of the Universe to communicate with each other. This means that they are not in causal contact. As a result there is no way for these two regions to have mixed together to reach a common temperature, as say as systems would which are in thermal equilibrium; or there is no way for these two regions to have synchronized their watches so that they would know that they should start expanding at the same time.
This is the HORIZON problem.