Keplerian motions arise for orbits in centrally concentrated systems. For
example, a very centrally condensed system is the Solar System where 99.9 %
of the mass is in the Sun and all of the other bodies orbit around the Sun in
orbits whose sizes
are much greater than the radius of the Sun.
For galaxies, Keplerian orbits would arise for objects which were
outside of the main concentration of mass of the galaxy. That is,
things which orbit at very large distances
are expected to show Keplerian motion. The point where
Keplerian motion starts roughly marks the edge of the galaxy.